91´óÉñ

The Neuroscience Research Center at 91´óÉñ Children’s works to develop innovative treatments that improve the lives of children with neurological disorders. Located in the Delaware Valley, our team leverages the synergy of a diverse team of clinical and basic science investigators. We collaborate across disciplines to advance pediatric research and provide exceptional care.&nbsp;</p>\r\n<p>We believe team science is the best science. We combine our expertise to understand the mechanisms underlying pediatric neurological disorders. Our work helps us better predict progression and develop treatments and prevention therapies that can improve quality of life for children everywhere.&nbsp;</p>\r\n<p>Our team includes experts in epilepsy, general neurology, neonatal neurology, neuro-ophthalmology, neuromuscular disorders, neuroimmunology and genetics. Flagship programs like our Level IV Epilepsy Center with advanced epilepsy monitoring unit and MDA-certified neuromuscular program highlight our leadership in these areas. We also train future leaders through our&nbsp;<a></a><a href=\"/content/nemours/us/en/education/gme.html\">robust neurology residency and fellowship programs</a>.</p>\r\n<p>With active clinical trials exploring new treatments for conditions like tuberous sclerosis, migraine, and Dravet syndrome, we are at the forefront in translating discoveries into real-world impact.&nbsp;</p>\r\n"}} id=text-d659e4d628 class=cmp-text>

The Neuroscience Research Center at 91´óÉñ Children’s works to develop innovative treatments that improve the lives of children with neurological disorders. Located in the Delaware Valley, our team leverages the synergy of a diverse team of clinical and basic science investigators. We collaborate across disciplines to advance pediatric research and provide exceptional care.Ìý

We believe team science is the best science. We combine our expertise to understand the mechanisms underlying pediatric neurological disorders. Our work helps us better predict progression and develop treatments and prevention therapies that can improve quality of life for children everywhere.Ìý

Our team includes experts in epilepsy, general neurology, neonatal neurology, neuro-ophthalmology, neuromuscular disorders, neuroimmunology and genetics. Flagship programs like our Level IV Epilepsy Center with advanced epilepsy monitoring unit and MDA-certified neuromuscular program highlight our leadership in these areas. We also train future leaders through ourÌýrobust neurology residency and fellowship programs.

With active clinical trials exploring new treatments for conditions like tuberous sclerosis, migraine, and Dravet syndrome, we are at the forefront in translating discoveries into real-world impact.Ìý

Our center advances the understanding and treatment of childhood neurological disorders through focused scientific investigation and collaborative research approaches. Our work is structured around dedicated focus areas and interconnected themes, creating a comprehensive framework that drives discovery and improves patient care.</p>\r\n<h2>Focus&nbsp;Areas&nbsp;</h2>\r\n<p>Our center includes research that focus primarily on:</p>\r\n<p><a href=\"/content/nemours/us/en/pediatric-research/research-labs/dynamics-epilepsy-cognitive-development.html\">Pediatric epilepsy and cognitive impairments</a><b> </b>|&nbsp;Investigating the cognitive and behavioral problems that can happen along with epilepsy to develop more targeted therapies.&nbsp;</p>\r\n<p><a href=\"/content/nemours/us/en/pediatric-research/research-labs/neonatal-brain-injury-lab.html\">Neonatal brain injury</a>&nbsp;|&nbsp;Delineating the mechanisms of perinatal brain injuries, especially hypoxic-ischemic encephalopathy using innovative models to identify protective therapies.&nbsp;</p>\r\n<p><b>Neurodevelopmental disorders and neurological cancers</b> | Exploring the molecular basis of cerebellar neurodevelopment to pinpoint new treatment therapies.&nbsp;</p>\r\n<p><b>Early-onset motor neuron disorders </b>|<b>&nbsp;</b><span>Uncovering the common pathways underlying diseases like spinal muscular atrophy and hereditary neuropathies to guide new treatments.</span></p>\r\n"}} id=text-6116fe6d69 class=cmp-text>

Our center advances the understanding and treatment of childhood neurological disorders through focused scientific investigation and collaborative research approaches. Our work is structured around dedicated focus areas and interconnected themes, creating a comprehensive framework that drives discovery and improves patient care.

FocusÌýAreasÌý

Our center includes research that focus primarily on:

Pediatric epilepsy and cognitive impairments |ÌýInvestigating the cognitive and behavioral problems that can happen along with epilepsy to develop more targeted therapies.Ìý

Neonatal brain injuryÌý|ÌýDelineating the mechanisms of perinatal brain injuries, especially hypoxic-ischemic encephalopathy using innovative models to identify protective therapies.Ìý

Neurodevelopmental disorders and neurological cancers | Exploring the molecular basis of cerebellar neurodevelopment to pinpoint new treatment therapies.Ìý

Early-onset motor neuron disorders |ÌýUncovering the common pathways underlying diseases like spinal muscular atrophy and hereditary neuropathies to guide new treatments.

We pursue projects that intersect across our main focus areas within the following themes:&nbsp;</p>\r\n<ul>\r\n<li><b>Multidisciplinary research collaboration:</b>&nbsp;Partnering with basic scientists, mathematicians, statisticians, and clinicians to advance insights and discoveries.</li>\r\n<li><b>Basic and translational research:</b>&nbsp;Turning today’s discoveries into tomorrow’s cures with the full range of research, from wet bench through clinical trials.</li>\r\n<li><b>Early intervention and prevention:</b>&nbsp;Investigating ways to predict outcomes for neurologic disease and identify new, early treatments.&nbsp;</li>\r\n<li><b>Improving quality of life:</b>&nbsp;Working to help kids with neurologic disorders live better in childhood and beyond.</li>\r\n</ul>\r\n"}} id=text-81bf902800 class=cmp-text>

We pursue projects that intersect across our main focus areas within the following themes:Ìý

• Multidisciplinary research collaboration:ÌýPartnering with basic scientists, mathematicians, statisticians, and clinicians to advance insights and discoveries.
• Basic and translational research:ÌýTurning today’s discoveries into tomorrow’s cures with the full range of research, from wet bench through clinical trials.
• Early intervention and prevention:ÌýInvestigating ways to predict outcomes for neurologic disease and identify new, early treatments.Ìý
• Improving quality of life:ÌýWorking to help kids with neurologic disorders live better in childhood and beyond.

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.</p>\r\n"}} id=text-41064531e1 class=cmp-text>

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.

Centers at 91´óÉñ often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.</p>\r\n"}} id=text-58cda32c32 class=cmp-text>

Centers at 91´óÉñ often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.

The strength of our research is reflected in scientific contributions and peer recognition. Through competitive grant funding, high-impact publications, and field-advancing discoveries, we demonstrate our commitment to rigorous science that improves children's lives. Here we highlight key indicators of our research productivity and scientific impact.</p>\r\n"}} id=text-f92ecac0d7 class=cmp-text>

The strength of our research is reflected in scientific contributions and peer recognition. Through competitive grant funding, high-impact publications, and field-advancing discoveries, we demonstrate our commitment to rigorous science that improves children's lives. Here we highlight key indicators of our research productivity and scientific impact.

Our research is recognized and validated through generous federal grants and private funding. In fact, we're part of Delaware State University’s National Institute of Health (NIH) Centers of Biomedical Research Excellence (COBRE) program working collaboratively on research pertaining to pediatric neurological disorders. This initiative fosters interdisciplinary collaboration between different institutions within the state of Delaware.</p>\r\n<p>This and other support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has recently been awarded:&nbsp;</p>\r\n<h2>National Institutes of Health (NIH)</h2>\r\n<p><b>R01 Grant</b><u><br>\r\n </u>Targeting mechanosignaling in pediatric brain tumors (2022-2027) | Langhans, S.A. (PI)</p>\r\n<p>Leveraging genetically encoded heterogeneity to understand TSC-associated neuropsychiatric disorders and seizures in novel models of tuberous sclerosis complex (2022-2027) | Hernan, A. (PI)</p>\r\n<p><b>Clinical and Translational Research Support Hub of Resources and Education (CTR-SHoRE)&nbsp;<br>\r\n </b>Leveraging genetic diversity to identify astrocytic modifiers of TSC phenotypes (2024) | Hernan, A.</p>\r\n<p><b>Centers of Biomedical Research Excellence (COBRE)&nbsp;— Team Science<br>\r\n </b>Functions of Na,K-ATPase beta1-subunit in cerebellar development and neurodevelopmental disorders&nbsp;(2024-2025) | Hernan, A. and Langhans, S.A. (PIs)</p>\r\n<p><b>Idea Networks of Biomedical Research Excellence (INBRE)&nbsp;</b></p>\r\n<p>Team Science Grant<br>\r\nSex and microglia in neonatal hypoxic ischemic brain injury (2024-2025) | Wright-Jin, E. (PI)</p>\r\n<p>Booster Grant<br>\r\nMulti-indication therapeutic strategies for early-onset motor neuron diseases (2024-2025) | Butchbach, M. (PI)</p>\r\n<h2>Private Funding</h2>\r\n<p><b>Holt Foundation<br>\r\n </b>Leveraging genetically-encoded heterogeneity to understand TSC-associated neuropsychiatric disorders and seizures in novel models of tuberous sclerosis complex (2023-2026) | Hernan, A. (PI)</p>\r\n<p><b>Thomas Jefferson University Center for Neurological Analytics<br>\r\n </b>Impact of inflammation on outcome after neonatal hypoxic ischemic encephalopathy (2024-2025) | Wright-Jin, E. (PI)</p>\r\n<p>Relationship between interferon regulatory factor 2 binding protein-like (IRF2BPL) and androgen receptor (AR) in motor neuron diseases (2024-2025) | Butchbach, M. (PI)</p>\r\n<p>Enhancing Associative Memory in Epilepsy Patients through Direct Brain Stimulation (2024-2025) | Scott, R. (PI)</p>\r\n<p><b>Delaware Health Sciences Alliance (DHSA)&nbsp;— Shark Tank<br>\r\n </b>Discerning the abnormal functional connectivity involving the social reciprocity network in Autism Spectrum Disorder and the impact of Transcranial Magnetic Stimulation in mitigating the abnormalities (2024-2025) | Scott, R. (PI)</p>\r\n<p><b>91´óÉñ Children’s Health Department of Pediatrics Operational Division&nbsp;<br>\r\n </b>Development of a Scorecard to Guide Prognosis in Neonates with Hypoxia-Ischemic Encephalopathy (2024) | Tran, L. (PI)</p>\r\n<p><b>Swank Foundation<br>\r\n </b>A complex system approach to improving outcomes in autism spectrum disorders (2022-)&nbsp;Scott, R. (PI)</p>\r\n"}} id=text-c6b28264e8 class=cmp-text>

Our research is recognized and validated through generous federal grants and private funding. In fact, we're part of Delaware State University’s National Institute of Health (NIH) Centers of Biomedical Research Excellence (COBRE) program working collaboratively on research pertaining to pediatric neurological disorders. This initiative fosters interdisciplinary collaboration between different institutions within the state of Delaware.

This and other support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has recently been awarded:Ìý

National Institutes of Health (NIH)

R01 Grant
Targeting mechanosignaling in pediatric brain tumors (2022-2027) | Langhans, S.A. (PI)

Leveraging genetically encoded heterogeneity to understand TSC-associated neuropsychiatric disorders and seizures in novel models of tuberous sclerosis complex (2022-2027) | Hernan, A. (PI)

Clinical and Translational Research Support Hub of Resources and Education (CTR-SHoRE)Ìý
Leveraging genetic diversity to identify astrocytic modifiers of TSC phenotypes (2024) | Hernan, A.

Centers of Biomedical Research Excellence (COBRE)Ìý— Team Science
Functions of Na,K-ATPase beta1-subunit in cerebellar development and neurodevelopmental disordersÌý(2024-2025) | Hernan, A. and Langhans, S.A. (PIs)

Idea Networks of Biomedical Research Excellence (INBRE)Ìý

Team Science Grant
Sex and microglia in neonatal hypoxic ischemic brain injury (2024-2025) | Wright-Jin, E. (PI)

Booster Grant
Multi-indication therapeutic strategies for early-onset motor neuron diseases (2024-2025) | Butchbach, M. (PI)

Private Funding

Holt Foundation
Leveraging genetically-encoded heterogeneity to understand TSC-associated neuropsychiatric disorders and seizures in novel models of tuberous sclerosis complex (2023-2026) | Hernan, A. (PI)

Thomas Jefferson University Center for Neurological Analytics
Impact of inflammation on outcome after neonatal hypoxic ischemic encephalopathy (2024-2025) | Wright-Jin, E. (PI)

Relationship between interferon regulatory factor 2 binding protein-like (IRF2BPL) and androgen receptor (AR) in motor neuron diseases (2024-2025) | Butchbach, M. (PI)

Enhancing Associative Memory in Epilepsy Patients through Direct Brain Stimulation (2024-2025) | Scott, R. (PI)

Delaware Health Sciences Alliance (DHSA)Ìý— Shark Tank
Discerning the abnormal functional connectivity involving the social reciprocity network in Autism Spectrum Disorder and the impact of Transcranial Magnetic Stimulation in mitigating the abnormalities (2024-2025) | Scott, R. (PI)

91´óÉñ Children’s Health Department of Pediatrics Operational DivisionÌý
Development of a Scorecard to Guide Prognosis in Neonates with Hypoxia-Ischemic Encephalopathy (2024) | Tran, L. (PI)

Swank Foundation
A complex system approach to improving outcomes in autism spectrum disorders (2022-)ÌýScott, R. (PI)