Neuroscience Research
Illuminating Discovery in Brain Health for Kids
At 91´óÉñ Children’s, our neuroscience research is reshaping how we understand and care for the developing brain.ÌýFrom drug-resistant epilepsy and brain injury at birth to conditions that affect cognition, behavior, and brain circuits — our work spans a full continuum of pediatric neuroscienceÌýconditions, helping children grow, learn, and thrive.Ìý
Our approach is deeply collaborative.ÌýOur researchers, neurologists, neurosurgeons, geneticists, and imaging scientists are united by a shared goal: to discover and deliver new treatments that improve lives.Ìý
Key Areas of ResearchÌý
Epilepsy, Seizure Risk & Brain Development |ÌýStudying how seizures affect memory, learning, and brain development while investigating the changing brain states that influence when seizures may happen.
Brain Circuits, Cognition & Stimulation |ÌýStudying how brain activity shapes learning, behavior, and cognition, and exploring whether targeted brain stimulation can help restore healthier patterns of network activity.
Neonatal Brain Injury |ÌýInvestigating how oxygen deprivation and inflammation at birth impact brain development and long-term outcomes.
Motor Neuron Diseases |ÌýIdentifying therapies that target shared disease mechanisms in rate motor neuron diseases like spinal muscle atrophy.
Precision Imaging & Drug DiscoveryÌý|ÌýDeveloping individualized treatments for brain conditions with advanced scans, 3D modeling, and genetic screening.
Brain Support Cells & Inflammation |ÌýExploring how cells like astrocytes and microglia influence seizures, healing, and the health of brain networks.
Metabolism & Brain Function |ÌýStudying how metabolic conditions like diabetes impact brain development, learning, and memory through imaging and cognitive studies.
Clinical Trials & Research Studies
Clinical trials are a critical part of how we bring discoveries from the lab into care. Our neuroscience researchers lead and participate in studies that test new therapies, technologies, and approaches to treating pediatric brain and nervous system conditions.
Our work includes trials focused on seizure prevention, brain injury recovery, advanced imaging, and personalized treatments for rare neurodevelopmental disorders. These studies help us improve care for the children we serve today, and generations to come.
Where Neuroscience Research Happens
Neuroscience research at 91´óÉñ brings together translational labs focused on brain development, imaging, and drug discovery. Our teams collaborate closely with experts in neurology, neurosurgery, neonatology, neurodevelopmental medicine, and endocrinology. We’re supported by integrated partnerships across the health system that help move discoveries to benefit children.Ìý
Related Research
Neuroscience Research Center
DELAWARE VALLEY
Our team investigates the developing brain and translates discoveries in imaging, behavior, and biology into better diagnostics and treatments for children.
Brain Stimulation for Treatment of Cognition Lab
DELAWARE VALLEY
Our lab investigates how noninvasive brain stimulation techniques can improve learning and behavior in children with neurological and developmental conditions.
Center for Endocrinology, Diabetes & Metabolism
NORTH FLORIDA
Our researchers study the mechanisms of hormone action and devise therapeutic strategies to replace or normalize hormonal levels to improve growth and functionality.
Dynamics in Epilepsy & Cognitive Development Lab
DELAWARE VALLEY
We study how early-life seizures impact brain development, using advanced recording and treatment strategies to support cognitive outcomes in children with epilepsy.
Neonatal Brain Injury Lab
DELAWARE VALLEY
We research birth-related brain injuries in newborns, including HIE, to help protect brain development and improve outcomes.
Neuromuscular Research, Central Florida
Our team studies neuromuscular diseases in children, focusing on early detection, genetic causes, and strategies to slow disease progression.
Quantitative Epilepsy State Tracking Lab
DELAWARE VALLEY
We study how changing brain states and biological rhythms influence seizure timing to advance forecasting and prevention for children with epilepsy.
Translational Neurobiology & Drug Discovery Lab
DELAWARE VALLEY
We study how brain cells grow and connect to understand the causes of pediatric brain tumors and neurodevelopmental disorders, and to develop more targeted therapies.
Translational Neuroimaging Lab
DELAWARE VALLEY
Our lab develops PET imaging agents to better detect pediatric neurological diseases and cancers, supporting diagnosis and treatment planning.
Neuroscience Clinical Care
Neuroscience Center, Delaware Valley
CLINICAL CARE
Pediatric neurology, epilepsy care, and neurodevelopmental services at 91´óÉñ Children’s Hospital, Delaware and throughout Greater Philadelphia.
Neuroscience Center, Central Florida
CLINICAL CARE
Complete pediatric neurology, neurosurgery, and neurodevelopmental services for children throughout Central Florida at 91´óÉñ Children’s Hospital, Florida.