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Our Areas of Focus

Impact of Maternal Inflammation

Maternal immune activation (inflammation)Ìý—Ìýor when the immune system responds to a perceived threat to the body during late pregnancy and childbirthÌý—Ìýsignificantly increases the risk for a birth-related brain injury. We are looking at how inflammation in mothers affects their baby by studying interactions of the mother, placenta, and baby. We want to find ways to reduce brain development problems in babies born to mothers with infections or inflammation.Ìý

Neuronal and Behavioral Impacts of Hypoxic Ischemic Encephalopathy (HIE)

HIE is a brain injury that happens when there is a lack of oxygen or blood flow to the brain around the time of birth. It can lead to learning problems, ADHD, mood disorders, epilepsy, and autism. We are looking at the effects of HIE on neurons (nerve cells) and behaviors in mouse models, both in the short- and long-term.Ìý

Microglia Identity After HIE

Microglia (the immune cells in the brain) and microglia-like monocytes are believed to be key players in the inflammatory response after HIE. The process of how these cells become activated and take on different roles is not yet understood. Additionally, the specific groups of cells within the larger population haven’t been fully studied or understood in newborns with HIE. We use advanced techniques, like bulk and single cell profiling, to identify subsets of microglia that develop so they may be targeted to control healing and recovery.