Orthopedics Department Research, AI duPont Campus
- About Us
- Our Research
- Research Impact
- Grants & Affiliations
Reshaping the Future of Pediatric Orthopedics Through Research
Researchers at 91´óÉñ Children’s in Delaware are globally recognized for transformative research in pediatric orthopedic conditions. Ranked in the Top 10 nationally byÌýU.S. News & World Report, our team brings together clinical expertise and scientific innovation to improve outcomes for children with bone, joint, muscle, and neurological conditions.Ìý
Our comprehensive approach spans from laboratory discoveries to clinical applications. Our team maintains a strong presence on the podium at major scientific meetings and publishes impactful work in orthopedic journals. This academic strength is built upon our leading roles in multicenter collaborations and national registries that collect and analyze data on thousands of children across North America.
We’ve established strategic partnerships with engineering teams, biomechanists, and data scientists at institutions including the University of Delaware, Villanova University, and the University of Calgary. These collaborations have furthered innovations in areas ranging from meniscal biomechanics to machine learning applications that improve surgical decision-making.
Our research hub is in Wilmington, Delaware at the Alfred I. duPont Campus located at 91´óÉñ Children’s Hospital, Delaware. Every discovery we make here gives kids everywhere the best chance for improved mobility, function, quality of life, and long-term health.
Excellence in Pediatric Orthopedics Research: By the Numbers
With over $6.5 million in active funding, our team of physician-scientists, research coordinators, and clinical collaborators are solving the most challenging pediatric orthopedic conditions.
#10Ìý
National ranking by U.S. News & World Report (2024-2025)Ìý
75+
Active research studies across our orthopedic specialties
51
Publications in peer-reviewed journals in 2024
15
Federal, foundation, and industry grants supporting our workÌý
Our researchÌýintegrates advanced biomechanical analysis and machine learningÌýto improve treatment decision-making and outcomes.
We'reÌýleading the field in understanding how disease-modifying therapies affect skeletal developmentÌýin children with neuromuscular disorders.
OurÌýresearchers lead international collaborationsÌýin pediatric spine, cerebral palsy, and skeletal dysplasia research.
We combine clinical trials with translational research, includingÌýgroundbreaking collaborations in meniscal biomechanics, spastic muscle properties, and 3D bioprinting.
91´óÉñ Orthopedics Research News & Announcements
Center Leadership

Suken A. Shah, MD, FAOA, FAAOSÌý
Shands/MacEwen Endowed Chair
Professor of Orthopedic SurgeryÌý
Pediatrics Department Chair

Jeanne Franzone, MD
Director of Orthopedic Research

Alice Taylor
Research Coordinator Lead
Research Coordinators
Research Team
Research Capabilities & Resources

Our research is supported by specialized resources and collaborations that enhance our understanding of pediatric orthopedic conditions. We partner with leading institutions including Thomas Jefferson University, BC Children’s Hospital, Gillette Children’s Hospital, the University of Delaware, Villanova University, Washington University, Baylor College of Medicine, University of Calgary,Ìýand others. We leverage expertise and advanced technologies.
- Gait & Motion Analysis Laboratory:ÌýOur internationally recognized lab assesses movement patterns in children with neuromuscular disorders, guiding surgical decisions and evaluating treatments.
- Tissue Engineering & Regenerative Medicine Lab:ÌýWith a state-of-the-art wet lab in collaboration with basic science and clinical researchers, we investigate the pathophysiologic properties of skeletal muscle contracture, machine learning for the early detection and diagnosis of cerebral palsy, and other translational research projects.
- Biobank and Molecular Analysis Program:ÌýInvestigating pathophysiologic properties of bone, muscle, joints, and cartilage for diagnoses such as skeletalÌýdysplasias, arthrogryposis, osteogenesis imperfecta, cerebral palsy and more.
- Patient registries and data analytics:ÌýWe track conditions such as cerebral palsy, scoliosis, and hip dysplasia, analyzing long-term outcomes to improve treatment success.ÌýSome of the multicenter registries we are involved inÌýinclude:ÌýtheÌýHarms Study Group, COMET trial, GHDR, SLIP, POISE and Rare Hip Registries within the Hip Hope Network, and others.
Pioneering Breakthroughs in Pediatric Orthopedic CareÌý

We’re at the center where engineering, clinical medicine, and data science converge to address the unique challenges of pediatric orthopedic conditions. Unlike adult orthopedics, we focus on the complexities of growing bones and developing bodies, where each intervention must account for years of future growth and development.
Focus Areas
We concentrate research efforts in these key areas.
Straightening Paths:ÌýScoliosis & Other Spinal Conditions Research
Our spine research directly impacts thousands of children with scoliosis and spinal deformities annually. By improving surgical techniques and pain management protocols, we help children experience less pain, shorter hospital stays, and better long-term outcomes. Our predictive models help families make informed decisions at optimal times, potentially avoiding more invasive procedures during crucial developmental years. Key research areas include:
- Anterior vertebral body tethering for progressive curves.
- Multimodal pain management following spine surgery.
- Predictive models for scoliosis progression and treatment response.
Restoring Function: Cerebral Palsy & Neuromuscular Disorders Research
Our research directly improves mobility and independence for children with cerebral palsy and neuromuscular disorders. We study how disease-modifying treatments affect skeletal development to help children maintain function and avoid complications. Our world-renowned gait laboratory informs precise, personalized surgical decisions that maximize each child's movement potential, helping them participate more fully in school, recreation, and family life. Specific initiatives help to:
- Leverage our large institutional CP database to answer key questions relating to gait function, hip instability, scoliosis, and more.
- Evaluate the effects of disease-modifying therapies on skeletal development.
- Perform translational research through international, national, and 91´óÉñ collaborations.
Correcting Rare Conditions: Skeletal Dysplasia Research
Children with skeletal dysplasias face unique challenges affecting multiple aspects of their lives. Our research into specialized surgical techniques and treatment approaches helps these children achieve better mobility, reduced pain, and improved function. By developing better corrections for limb deformities and spinal complications, we help children with rare conditions participate more fully in activities and gain independence. Current investigations include:
- Specialized surgical techniques for limb deformities in achondroplasia.
- Spinal complications and cervical spine instability management.
- Natural history studies of rare skeletal disorders.
Strengthening Foundations: Osteogenesis Imperfecta Research
Our approach to treating osteogenesis imperfecta (OI) has demonstrated excellent outcomes with dramatically reduced complication rates. By developing specialized techniques and comprehensive care approaches, we help children with OI achieve greater independence and improved function despite their complex condition, allowing more participation in everyday activities. Current research focuses on:
- Multimodal approaches to treating severe scoliosis in OI patients.
- Surgical techniques for limb deformity correction in OI.
- Effects of bisphosphonate treatment on bone quality and fracture healing.
Advancing Movement Science: Gait Laboratory Research
Our internationally recognized gait laboratory transforms how we understand and treat movement disorders in children. By analyzing the complex interactions during walking, we precisely identify mobility challenges and design targeted interventions. This ensures children receive exactly what they need, maximizing functional improvements that help them play, learn, and develop alongside their peers. Key areas include:
- Developing predictive models for surgical decision-making using gait data.
- Evaluating long-term functional outcomes following multi-level surgeries.
- Creating new assessment tools to quantify movement quality in clinical settings.
Rebuilding Possibilities: Lower & Upper Limb Reconstruction ResearchÌý
For children with limb differences, our reconstruction research opens doors to greater independence and participation. By developing innovative approaches to prosthetics, limb lengthening, and pain management, we help children overcome physical limitations and develop confidence. These advancements improve not only physical function but also how children view themselves and their future possibilities. Our current research includes:
- Novel prosthetic systems for pediatric limb deficiency.
- Intramedullary techniques for limb lengthening.
- Psychological aspects of limb reconstruction procedures.
Preserving Mobility: Hip Disorders Research
Our research on hip disorders addresses conditions crucial for children's mobility and long-term joint health. By studying hip displacement patterns, surveillance protocols, and reconstructive techniques, we help prevent painful complications and preserve function. Early detection and intervention for conditions like developmental hip dysplasia can mean the difference between normal mobility and lifelong limitations, improving outcomes for children from infancy through adolescence. Our studies investigate:
- Hip displacement patterns in cerebral palsy and neuromuscular disorders.
- Surveillance protocols for at-risk populations.
- Long-term functional outcomes following pediatric hip interventions.
Returning to Play: Sports Medicine ResearchÌý
Our sports medicine research focuses on the unique needs of young athletes, addressing both injury treatment and prevention. By developing age-appropriate procedures and rehabilitation protocols, we help injured children return to sports safely while reducing reinjury risk. This research not only addresses immediate injuries but promotes long-term joint health and continued participation in physical activities that are vital for children's development and well-being. Current studies investigate:
- ACL reconstruction techniques and outcomes in adolescents.
- Prevention programs for common athletic injuries.
- Management of growth plate injuries in young athletes.
Research Themes
Our research is guided by several core themes:
- Clinical excellence through evidence-based practice:ÌýWe rigorously evaluate treatments to determine which approaches deliver the best outcomes for our patients.
- Conducting efficient, informative research:ÌýWe quickly translate laboratory discoveries into real treatments to help children today and advance pediatric medicine tomorrow.
- Advocating for accessible orthopedic care:ÌýOur research examines socioeconomic and racial disparities in orthopedic outcomes to develop more accessible treatment approaches.
- Leading through data-driven insight:ÌýOur comprehensive data management across orthopedic subspecialties transforms patient outcomes into better treatments.
Clinical Trials & Research Studies at 91´óÉñ
Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.

Publications
91´óÉñ researchers constantly contribute to advancing scientific understanding. We share our knowledge, insights, and discoveries to encourage collaboration and inspire further research.
Making a Difference in Children’s Lives
Across all our specialties, we share a vision for our patients to thrive beyond their orthopedic conditions. Our impact spans from laboratory innovations to clinical applications, from improving surgical outcomes to enhancing quality of life. Here's how we make a difference.
Advancing Surgical Techniques & Clinical Care
Our research has directly led to improved approaches that benefit children worldwide:
- The multimodal approach to treating severe scoliosis in patients with osteogenesis imperfecta, developed at 91´óÉñ, has demonstrated excellent midterm outcomes with dramatically reduced complication rates.
- Our work on hip displacement in neuromuscular conditions has informed surveillance protocols that identify at-risk patients earlier, enabling less invasive interventions.
Optimizing Health Care Delivery & Access
We’re changing how and where children receive orthopedic care:
- Telehealth research for less severe orthopedic injuries has reduced unnecessary emergency department visits, creating time and cost savings for families.
- Our outcomes-based research evaluates the impacts of new technologies to improve care efficiency and effectiveness.
- Our approach to socioeconomic and racial disparities in orthopedic outcomes has developed more equitable treatment approaches.
Improving Functional Outcomes
Our focus on long-term function has changed how we evaluate treatment success:
- The integration of advanced gait analysis with machine learning has improved surgical planning precision for children with cerebral palsy.
- Long-term studies tracking changes in muscle strength and mobility after multi-level orthopedic surgery have shaped post-operative rehabilitation protocols.
- Our findings on the on the causes of anterior pelvic tilt in CP have refined surgical decision-making.
- Research on foot posture changes throughout childhood has informed intervention timing for optimal functional results.
Pioneering Monitoring & Assessment
Our development of specialized assessment tools has transformed clinical care:
- Our National Institutes of Health (NIH)-funded pulmonary function assessment device improves surgical safety for children with complex conditions.
- The photo-based Modified Foot Posture Index we validated provides a reliable, non-invasive method to quantify foot deformities.
- Our spine growth potential research based on Sanders maturation staging has enhanced treatment timing decisions.
- Our methods for evaluating sagittal alignment in adolescent idiopathic scoliosis have improved both surgical and bracing outcomes.
Shaping Evidence-Based Practice
Our contributions to the scientific literature have established best practices in pediatric orthopedics:
- 51 scientific publications in 2024 alone, with 24 in high-impact orthopedic journals.
- Leadership in multicenter research initiatives including the Harms Study Group, COMET trial, and Global Hip Dysplasia Registry.
- Best Paper Award at the 2024 Gait and Clinical Movement Assessment Society Meeting for work on anterior pelvic tilt in cerebral palsy.
- Our research on disease-modifying therapies for neuromuscular disorders has established monitoring guidelines for orthopedic complications.
Leading Innovation in Pediatric Orthopedic Research
Our commitment to advancing the field extends beyond clinical care:
- Establishment of the Alfred I. duPont Medical Student Research Fellowship to cultivate the next generation of orthopedic researchers.
- Translational research collaborations with biomedical engineers and kinesiologists on meniscal biomechanics, machine learning, and spastic muscle properties.
- Pioneering work in understanding the orthopedic manifestations of rare genetic disorders.
Related Research & Clinical Focus
Centers at 91´óÉñ often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.
Cardiac Research
RESEARCH AREA
Our researchers study congenital and acquired heart conditions to advance pediatric cardiology through innovation in diagnosis, treatment, and outcomes.
Emergency Medicine Research
RESEARCH AREA
We improve pediatric emergency care through quality initiatives, innovation, and multi-site studies conducted in collaboration with national research networks.
Orthopedics Center, Delaware Valley
CLINICAL CARE
Pediatric orthopedic care including neuromuscular, spine, and limb conditions at 91´óÉñ Children’s Hospital, Delaware and throughout Greater Philadelphia.
Orthopedics Research
RESEARCH AREA
Our teams study bone, joint, and muscle development to improve care for children with orthopedic conditions through innovation and collaboration.
Pulmonology Research
RESEARCH AREA
Our teams explore lung development and respiratory disease to improve care for children through imaging, monitoring tools, and treatment innovation.
Radiology Research
RESEARCH AREA
Our researchers advance pediatric imaging by developing safer, clearer techniques that improve diagnosis, monitoring, and treatment of childhood conditions.
Skeletal Dysplasia Lab
DELAWARE VALLEY
Our lab is developing innovative gene therapies and treatments for rare skeletal disorders, specializing in Morquio A syndrome and other inherited conditions.
Supporting Discoveries Through Grants & Strategic Partnerships

Through prestigious grants, collaborative projects, and recognized excellence, we're working toward our vision of improving outcomes for children with orthopedic conditions.
Research Partnerships
We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study.
National Research Collaboratives & Consortia
- (SSSF)Ìý— Advancing scoliosis research and treatmentÌý
- Ìý— Global research collaborative for spinal deformityÌý
- (CPRN) — Collaborative research on cerebral palsy
- Research in Neuromuscular Orthopaedics (RINO) Study GroupÌý— Advancing research in neuromuscular disorders
- Ìý— Research network for pediatric hip disorders
- Fox Pediatric Congenital Spinal Deformity StudyÌý— Multicenter study of congenital spine conditions
University & Institutional Collaborations
- Ìý— Biomechanical research collaborationÌý
- Ìý— Machine learning and artificial intelligence applicationsÌý
- Ìý— Spastic muscle properties researchÌý
- Ìý— Clinical and translational research partnerÌý
- Ìý— Cerebral palsy research collaborationÌý
- Ìý— Scoliosis research partnerÌý
Professional Societies
- (SRS)Ìý— International society for spinal deformity researchÌý
- (AACPDM)Ìý— Research and clinical care for cerebral palsyÌý
- (IPOS)Ìý— Global pediatric orthopedic researchÌý
- (POSNA)Ìý— Advancing pediatric orthopedic care
Grants &ÌýFunding

Our research is recognized and validated through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has been awarded over $6.5 million in active grant funding, including:
National Institutes of Health (NIH)
U01 GrantÌý|ÌýIMPACT: Cost or Operation for Medical Epicondyle fracture Treatment in Children (2021-2025) | Franzone, J.M. (Site PI) | $1,000,000
R21 GrantÌý|ÌýNon-invasive Measurement of Pulmonary Dysfunction in Children with Cerebral Palsy (2023-2025) | Rahman, T. (Lead PI) | $389,777
R01 GrantÌý| Chronic post-surgical pain in Cerebral Palsy (2023-2025) | Shrader, M.W. (Site PI) | $125,343
Setting Scoliosis Straight Foundation (SSSF)
Scoliosis Database RegistryÌý| Idiopathic Scoliosis Outcomes Database Registry (2001-2025) | Shah, S. (Site PI) | $2,000,000
CP Scoliosis Prospective RegistryÌý| Prospective Study of Children with Cerebral Palsy (2008-2025) | Shah, S. (Site PI) | $1,000,000
Brittle Bone Disorder Consortium
Brittle Bone Disorder 7701Ìý| Multi-center collaborative research (2017-2025) | Franzone, J. (Site PI) | $66,654
Additional Research Support
Our researchers have secured an additional $1.5 million in funding from organizations including:
- American Orthopedic Society for Sports MedicineÌý
- University of British ColumbiaÌý
- Canadian Institutes of Health Research
- Pediatric Orthopedic Society of North AmericaÌý
- Cerebral Palsy Research NetworkÌý
- Hip Hope NetworkÌý