91大神

The 91大神 Cardiac Center for Research &amp; Innovation in Delaware Valley leads groundbreaking research and is committed to solving the most pressing challenges in children's heart health. With more than 20 investigators and $1 million in annual research funding, we are advancing how doctors detect, treat, and prevent pediatric heart disease.</p>\r\n<p>We lead through funded, clinically mission-aligned research priorities that promote the 鈥渨hole child鈥檚 health鈥� and address the major threats to child well-being across the lifespan. Through our vast and growing access to large data networks with the <a href=\"/content/nemours/us/en/pediatric-research/centers-programs/biomedical-research-informatics.html\">Biomedical Research Informatics Center</a>, we leverage the power of big data to uncover the drivers of poor cardiovascular health and outcomes. We partner with other leading hospitals, research centers, and primary care physicians nationwide to improve children's heart health through the design of novel, pragmatic interventions and <a href=\"/content/nemours/us/en/pediatric-research/clinical-trials/cardiac.html\">clinical trials</a>.</p>\r\n<p>Our work spans making heart surgery safer, improving clinical and neurodevelopmental outcomes following cardiac surgery, providing innovative ways to support families and babies with heart conditions, and developing novel strategies for diagnosing and treating high blood pressure and cholesterol in youth. We implement quality improvement initiatives to enhance hypertension management and lipid screening, preventing early cardiovascular disease and translating discoveries into better care for kids.</p>\r\n<p>Our research center is also active in training the next generation of researchers. We offer pilot grant funding and mentorship to early-stage investigators within our center and partner with internal funding and research mentorship programs within the Delaware Valley.</p>\r\n"}} id=text-90d8d78009 class=cmp-text>

The 91大神 Cardiac Center for Research & Innovation in Delaware Valley leads groundbreaking research and is committed to solving the most pressing challenges in children's heart health. With more than 20 investigators and $1 million in annual research funding, we are advancing how doctors detect, treat, and prevent pediatric heart disease.

We lead through funded, clinically mission-aligned research priorities that promote the 鈥渨hole child鈥檚 health鈥� and address the major threats to child well-being across the lifespan. Through our vast and growing access to large data networks with the Biomedical Research Informatics Center, we leverage the power of big data to uncover the drivers of poor cardiovascular health and outcomes. We partner with other leading hospitals, research centers, and primary care physicians nationwide to improve children's heart health through the design of novel, pragmatic interventions and clinical trials.

Our work spans making heart surgery safer, improving clinical and neurodevelopmental outcomes following cardiac surgery, providing innovative ways to support families and babies with heart conditions, and developing novel strategies for diagnosing and treating high blood pressure and cholesterol in youth. We implement quality improvement initiatives to enhance hypertension management and lipid screening, preventing early cardiovascular disease and translating discoveries into better care for kids.

Our research center is also active in training the next generation of researchers. We offer pilot grant funding and mentorship to early-stage investigators within our center and partner with internal funding and research mentorship programs within the Delaware Valley.

Our researchers investigate all aspects of cardiovascular health in children. Though our research is broad and exploratory, our efforts have coalesced around some key focus areas and themes.&nbsp;</p>\r\n<h3><b>Getting Heart Surgery Right: Congenital Heart Surgery &amp; Outcomes</b></h3>\r\n<p>We study outcomes and recovery after heart surgery. By tracking how children do after certain types of surgery and sharing what we learn with other hospitals, we're helping doctors choose the best surgical options for each child. This can mean better outcomes and healthier lives for kids who need heart surgery.</p>\r\n<h3><b>Seeing Inside Little Hearts: Cardiac Imaging</b></h3>\r\n<p>We're researching ways to make heart imaging better and clearer. This research helps doctors identify risk factors and find heart problems sooner, for more accurate treatments. We work with other hospitals in collaborative groups, like the Fetal Heart Society, and conduct industry sponsored projects to keep improving cardiac imaging for kids.</p>\r\n<h3><b>Helping Hearts Before Birth: Fetal &amp; Perinatal Cardiology</b></h3>\r\n<p>We're working to find heart problems earlier&nbsp;鈥�&nbsp;even before babies are born. This helps families and doctors prepare better and start treatment as soon as possible, giving babies the best chance at a healthy start in life.</p>\r\n<h3><b>Supporting Hearts and Minds: Developmental &amp; Emotional Health</b></h3>\r\n<p>We know that heart conditions affect more than just the heart. They impact a child's development and emotional well-being too. We help families prepare for having a baby with a heart condition and potential neurodevelopmental complications they may face. We also study how to support children with both heart conditions and developmental needs, like those with Down Syndrome.</p>\r\n<h3><b>Preventing Heart Problems: Preventive Cardiology</b></h3>\r\n<p>We're researching ways to stop heart problems before they start by focusing on risk factors such as high blood pressure and high cholesterol. We are leading studies to improve how we detect and diagnose high blood pressure in young people. Using large, national data sets, we鈥檙e answering important questions about cardiovascular health in youth. Recently, we were one of two sites in the country offering a new treatment for a rare form of high cholesterol.</p>\r\n<h3><b>Tracking Multisystem Inflammatory Syndrome in Children (MIS-C) Impact: Cardiovascular Complications</b></h3>\r\n<p>We're part of a nationwide team studying how MIS-C complications impact children's hearts. By following the health of many children over time, we're discovering the best ways to protect kids' hearts from MIS-C complications and treat any heart-related problems that might develop.&nbsp;</p>\r\n<h3><b>Understanding Heart Genes: Cardiovascular Genetics</b></h3>\r\n<p>We study how genes affect heart conditions, which helps us understand why some children are born with heart problems and how we can better treat them. This research helps doctors predict potential heart issues and plan the best treatments.</p>\r\n<h3><b>Making Heart Care Better for Everyone: Social Determinants of Cardiovascular Disease</b></h3>\r\n<p>We look at how a child's neighborhood and family situation affect their heart health care. We're finding ways to make sure every child gets excellent heart care, no matter what.</p>\r\n<h3><b>Making Heart Care Safer &amp; Smoother: Quality Improvement</b></h3>\r\n<p>By working with other hospitals through groups like the National Pediatric Cardiology Quality Improvement Collaborative and others, we learn and share the best ways to do heart tests and treatments. We've also created better ways to help families when it's time to go home from the hospital, making sure they have everything they need to keep their child healthy. This means less stress for families and better care for every child, especially those who need extra support.</p>\r\n<h3><b>Personalizing Heart Care: Outcomes &amp; Biomarkers Research&nbsp;</b></h3>\r\n<p>We鈥檙e studying ways to measure heart health without invasive procedures, using methods like exercise tests and feedback from patients themselves. Tracking these markers and listening to patients and families helps us better understand what works best for each child. This translates to customized care plans and improved long-term quality of life for children with heart conditions.&nbsp;</p>\r\n"}} id=text-a2929b44b3 class=cmp-text>

Our researchers investigate all aspects of cardiovascular health in children. Though our research is broad and exploratory, our efforts have coalesced around some key focus areas and themes.听

Getting Heart Surgery Right: Congenital Heart Surgery & Outcomes

We study outcomes and recovery after heart surgery. By tracking how children do after certain types of surgery and sharing what we learn with other hospitals, we're helping doctors choose the best surgical options for each child. This can mean better outcomes and healthier lives for kids who need heart surgery.

Seeing Inside Little Hearts: Cardiac Imaging

We're researching ways to make heart imaging better and clearer. This research helps doctors identify risk factors and find heart problems sooner, for more accurate treatments. We work with other hospitals in collaborative groups, like the Fetal Heart Society, and conduct industry sponsored projects to keep improving cardiac imaging for kids.

Helping Hearts Before Birth: Fetal & Perinatal Cardiology

We're working to find heart problems earlier听鈥斕齟ven before babies are born. This helps families and doctors prepare better and start treatment as soon as possible, giving babies the best chance at a healthy start in life.

Supporting Hearts and Minds: Developmental & Emotional Health

We know that heart conditions affect more than just the heart. They impact a child's development and emotional well-being too. We help families prepare for having a baby with a heart condition and potential neurodevelopmental complications they may face. We also study how to support children with both heart conditions and developmental needs, like those with Down Syndrome.

Preventing Heart Problems: Preventive Cardiology

We're researching ways to stop heart problems before they start by focusing on risk factors such as high blood pressure and high cholesterol. We are leading studies to improve how we detect and diagnose high blood pressure in young people. Using large, national data sets, we鈥檙e answering important questions about cardiovascular health in youth. Recently, we were one of two sites in the country offering a new treatment for a rare form of high cholesterol.

Tracking Multisystem Inflammatory Syndrome in Children (MIS-C) Impact: Cardiovascular Complications

We're part of a nationwide team studying how MIS-C complications impact children's hearts. By following the health of many children over time, we're discovering the best ways to protect kids' hearts from MIS-C complications and treat any heart-related problems that might develop.听

Understanding Heart Genes: Cardiovascular Genetics

We study how genes affect heart conditions, which helps us understand why some children are born with heart problems and how we can better treat them. This research helps doctors predict potential heart issues and plan the best treatments.

Making Heart Care Better for Everyone: Social Determinants of Cardiovascular Disease

We look at how a child's neighborhood and family situation affect their heart health care. We're finding ways to make sure every child gets excellent heart care, no matter what.

Making Heart Care Safer & Smoother: Quality Improvement

By working with other hospitals through groups like the National Pediatric Cardiology Quality Improvement Collaborative and others, we learn and share the best ways to do heart tests and treatments. We've also created better ways to help families when it's time to go home from the hospital, making sure they have everything they need to keep their child healthy. This means less stress for families and better care for every child, especially those who need extra support.

Personalizing Heart Care: Outcomes & Biomarkers Research听

We鈥檙e studying ways to measure heart health without invasive procedures, using methods like exercise tests and feedback from patients themselves. Tracking these markers and listening to patients and families helps us better understand what works best for each child. This translates to customized care plans and improved long-term quality of life for children with heart conditions.听

Our research touches on these recurring themes:</p>\r\n<ul>\r\n<li><b>Clinical trials research:</b>&nbsp;We carefully study new medicines and treatments to make sure they're safe and effective for children with heart conditions. These studies help us find the best ways to help each child.</li>\r\n<li><b>Translating discoveries:</b>&nbsp;When we learn something new about children's heart health, we work quickly to turn that knowledge into real treatments that doctors can use to help their patients right away.</li>\r\n<li><b>Health equity:</b>&nbsp;We're committed to making sure all children have access to the best heart care, no matter where they live or what resources their families have. We look for ways to overcome barriers that some families face in getting top-quality care.</li>\r\n<li><b>Population health:&nbsp;</b>By studying data from thousands of children, we can spot patterns and trends that help us understand heart conditions better. This big picture view helps us improve care for all kids.</li>\r\n<li><b>Data integration:&nbsp;</b>We combine different types of information like heart images, genetic data, and treatment results to get a complete picture of each child's heart health. This helps us personalize care for each patient.</li>\r\n<li><b>Implementation and dissemination science:&nbsp;</b>When we find treatments and approaches that work well, we share them with doctors and hospitals everywhere. We help create clear guidelines so all communities can benefit from the latest advances in children's heart care.</li>\r\n</ul>\r\n"}} id=text-e0b67d2ef5 class=cmp-text>

Our research touches on these recurring themes:

• Clinical trials research:听We carefully study new medicines and treatments to make sure they're safe and effective for children with heart conditions. These studies help us find the best ways to help each child.
• Translating discoveries:听When we learn something new about children's heart health, we work quickly to turn that knowledge into real treatments that doctors can use to help their patients right away.
• Health equity:听We're committed to making sure all children have access to the best heart care, no matter where they live or what resources their families have. We look for ways to overcome barriers that some families face in getting top-quality care.
• Population health:听By studying data from thousands of children, we can spot patterns and trends that help us understand heart conditions better. This big picture view helps us improve care for all kids.
• Data integration:听We combine different types of information like heart images, genetic data, and treatment results to get a complete picture of each child's heart health. This helps us personalize care for each patient.
• Implementation and dissemination science:听When we find treatments and approaches that work well, we share them with doctors and hospitals everywhere. We help create clear guidelines so all communities can benefit from the latest advances in children's heart care.

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.</p>\r\n"}} id=text-b29927f94b class=cmp-text>

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.

We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study. Partnerships include:</p>\r\n<ul>\r\n<li><a href=\"https://www.pediatricheartnetwork.org\" target=\"_blank\" rel=\"noopener noreferrer\">Pediatric Heart Network</a>&nbsp;鈥� Connects top heart centers across North America to share discoveries and improve care for all children with heart conditions</li>\r\n<li><a href=\"https://www.de-ctr.org/\" target=\"_blank\" rel=\"noopener noreferrer\">Delaware CTR ACCEL Program</a>&nbsp;鈥� Speeds up the process of turning laboratory discoveries into real treatments that can help children sooner</li>\r\n<li><a href=\"https://de-inbre.org\" target=\"_blank\" rel=\"noopener noreferrer\">Delaware INBRE</a>&nbsp;鈥� Links researchers across Delaware to combine expertise and create innovative solutions for children's heart care</li>\r\n<li>Delaware COBRE&nbsp;鈥� Builds excellence in medical research by supporting promising studies and training tomorrow's heart experts</li>\r\n<li><a href=\"https://pedsnet.org\" target=\"_blank\" rel=\"noopener noreferrer\">PEDSNet</a>&nbsp;鈥� Learns from millions of children's health records to understand which treatments work best for different heart conditions</li>\r\n<li><a href=\"https://www.pcori.org\" target=\"_blank\" rel=\"noopener noreferrer\">Patient Centered Outcomes Research Institute</a>&nbsp;(PCORI)&nbsp;鈥� Ensures our research addresses what matters most to families and improves quality of life for children with heart conditions</li>\r\n</ul>\r\n"}} id=text-a79ca1e3b5 class=cmp-text>

We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study. Partnerships include:

• 听鈥� Connects top heart centers across North America to share discoveries and improve care for all children with heart conditions
• 听鈥� Speeds up the process of turning laboratory discoveries into real treatments that can help children sooner
• 听鈥� Links researchers across Delaware to combine expertise and create innovative solutions for children's heart care
• Delaware COBRE听鈥� Builds excellence in medical research by supporting promising studies and training tomorrow's heart experts
• 听鈥� Learns from millions of children's health records to understand which treatments work best for different heart conditions
• 听(PCORI)听鈥� Ensures our research addresses what matters most to families and improves quality of life for children with heart conditions

Centers at 91大神 often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.</p>\r\n"}} id=text-45c9033cf1 class=cmp-text>

Centers at 91大神 often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.

Research is only as valuable as its ability to move the field forward, whether that means discovering and clarifying disease causes, learning new insights around preventing disease, or developing new and innovative ways to approach care and treatment.&nbsp;</p>\r\n<p>We identify our impact by the grants we鈥檝e received, the work we鈥檝e presented and published, and the national leadership roles our researchers have.&nbsp;</p>\r\n"}} id=text-23df1721e4 class=cmp-text>

Research is only as valuable as its ability to move the field forward, whether that means discovering and clarifying disease causes, learning new insights around preventing disease, or developing new and innovative ways to approach care and treatment.听

We identify our impact by the grants we鈥檝e received, the work we鈥檝e presented and published, and the national leadership roles our researchers have.听

Our research is recognized and validated through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has recently been awarded:&nbsp;</p>\r\n<h3>National Institute of General Medical Sciences (NIGMS)</h3>\r\n<p><b>Research Expanding Access to Child Health (REACH) Subaward</b> | 91大神 Move to Enhance Systemic hypertension confirmation in primary care Sites (NEMESIS)<b>&nbsp;</b>(2025-2027) | Baker-Smith, D (PI) | $456,000<br>\r\n</p>\r\n<p><b>Federal Supplement </b>|&nbsp;Feasibility and Acceptance of Early Ambulatory Blood Pressure Monitoring for Enhanced Pediatric Hypertension Diagnosis within a High Deprivation Community (2023-2024) | Baker-Smith, C. (PI) | $173,311</p>\r\n<p><b>Federal Subaward </b>|&nbsp;Team Science (2023-2024) | Baker-Smith, C. (PI) | $176,546 &nbsp;&nbsp;</p>\r\n<p><b>REACH Subaward </b>|&nbsp;HEARTPrep: A Virtually-Delivered Psychosocial Intervention for Mothers Expecting a Baby with Congenital Heart Disease (2022-2027) | Sood, E. (PI) | $646.041</p>\r\n<h3>Agency for Healthcare Research and Quality (AHRQ)</h3>\r\n<p><b>Federal Subaward </b>|&nbsp;PedsNet Scholars Project on Improving Pediatric Hypertension Detection Using Implementation Science (2022-2024) | Zaidi, A. (PI) | $265,248</p>\r\n<h3>Funded Trials</h3>\r\n<p><b>Pediatric Heart Network<br>\r\n </b>MUSIC: Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children | Srivastava, S. (PI)&nbsp;</p>\r\n<p><b>Pfizer<br>\r\n </b>Comirnaty COVID-19 Vaccine Study in People Less Than 21 Years Old | Thacker, D. (PI)</p>\r\n<p><b>Mezzion Pharma<br>\r\n </b>Fontan Udenafil Exercise Longitudinal Assessment Trial | Cartoski, M. (PI)</p>\r\n<p><b>Tenaya</b><br>\r\nNatural History Study in Pediatric Patients with MYBPC3 Mutation-associated Cardiomyopathy (MyCLIMB) | Tsuda, T. (PI)</p>\r\n<p><b>Merck</b><br>\r\nAn Operationally Seamless Phase 2/3 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Enlicitide Decanoate in Pediatric Participants with Heterozygous Familial Hypercholesterolemia |&nbsp;Baker-Smith, C., Connolly, S. (Co-PI)</p>\r\n"}} id=text-8a64bfa0fb class=cmp-text>

Our research is recognized and validated through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has recently been awarded:听

National Institute of General Medical Sciences (NIGMS)

Research Expanding Access to Child Health (REACH) Subaward | 91大神 Move to Enhance Systemic hypertension confirmation in primary care Sites (NEMESIS)听(2025-2027) | Baker-Smith, D (PI) | $456,000

Federal Supplement |听Feasibility and Acceptance of Early Ambulatory Blood Pressure Monitoring for Enhanced Pediatric Hypertension Diagnosis within a High Deprivation Community (2023-2024) | Baker-Smith, C. (PI) | $173,311

Federal Subaward |听Team Science (2023-2024) | Baker-Smith, C. (PI) | $176,546 听听

REACH Subaward |听HEARTPrep: A Virtually-Delivered Psychosocial Intervention for Mothers Expecting a Baby with Congenital Heart Disease (2022-2027) | Sood, E. (PI) | $646.041

Agency for Healthcare Research and Quality (AHRQ)

Federal Subaward |听PedsNet Scholars Project on Improving Pediatric Hypertension Detection Using Implementation Science (2022-2024) | Zaidi, A. (PI) | $265,248

Funded Trials

Pediatric Heart Network
MUSIC: Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children | Srivastava, S. (PI)听

Pfizer
Comirnaty COVID-19 Vaccine Study in People Less Than 21 Years Old | Thacker, D. (PI)

Mezzion Pharma
Fontan Udenafil Exercise Longitudinal Assessment Trial | Cartoski, M. (PI)

Tenaya
Natural History Study in Pediatric Patients with MYBPC3 Mutation-associated Cardiomyopathy (MyCLIMB) | Tsuda, T. (PI)

Merck
An Operationally Seamless Phase 2/3 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Enlicitide Decanoate in Pediatric Participants with Heterozygous Familial Hypercholesterolemia |听Baker-Smith, C., Connolly, S. (Co-PI)

Researchers at 91大神 Children's are often recognized for their exceptional contributions to pediatric research. Our team鈥檚 passion to advance children鈥檚 health and well-being is celebrated in these recent honors:</p>\r\n<p><b>Setting National Standards</b></p>\r\n<ul>\r\n<li>Lead development of scientific statements and clinical guidelines that shape pediatric cardiology care nationwide.</li>\r\n<li>Hold key positions on scientific committees and editorial boards of major medical journals.</li>\r\n</ul>\r\n<p><b>Sharing Knowledge</b></p>\r\n<ul>\r\n<li>Publish research in leading medical journals.</li>\r\n<li>Present findings at major scientific meetings including:<ul>\r\n<li>American Heart Association</li>\r\n<li>American College of Cardiology</li>\r\n<li>Pediatric Academic Society</li>\r\n</ul>\r\n</li>\r\n</ul>\r\n<p><b>Training Future Leaders</b></p>\r\n<ul>\r\n<li>Provide research mentorship and oversight for cardiology fellows.</li>\r\n<li>Support next generation of pediatric heart specialists.</li>\r\n</ul>\r\n"}} id=text-3b5d55bd71 class=cmp-text>

Researchers at 91大神 Children's are often recognized for their exceptional contributions to pediatric research. Our team鈥檚 passion to advance children鈥檚 health and well-being is celebrated in these recent honors:

Setting National Standards

• Lead development of scientific statements and clinical guidelines that shape pediatric cardiology care nationwide.
• Hold key positions on scientific committees and editorial boards of major medical journals.

Sharing Knowledge

• Publish research in leading medical journals.
• Present findings at major scientific meetings including:
  • American Heart Association
  • American College of Cardiology
  • Pediatric Academic Society

Training Future Leaders

• Provide research mentorship and oversight for cardiology fellows.
• Support next generation of pediatric heart specialists.