91´óÉñ

The Biomedical Research Informatics Center (BRIC) is a vital resource supporting innovative research at 91´óÉñ Children’s. We provide specialized expertise, computational tools, and a robust data infrastructure that helps researchers unlock new insights and accelerate groundbreaking discoveries. &nbsp;</p>\r\n<p>Our team collaborates with basic scientists, clinicians, and data experts across 91´óÉñ and national research networks like PEDSnet. We leverage advanced analytics, bioinformatics, biostatistics, and machine learning to uncover meaningful, actionable information from large datasets like electronic health records (EHR), genomic sequencing, and clinical observations.&nbsp;</p>\r\n<p>BRIC plays an important role in 91´óÉñ precision medicine initiatives. Our work helps to develop disease biomarkers and identify promising treatments. We also fuel multisite clinical trials and studies aimed at improving care and health outcomes for kids.&nbsp;</p>\r\n<p>With a world-class computational infrastructure, cutting-edge software, and specialized training, our team empowers researchers to solve complex pediatric health challenges.&nbsp;</p>\r\n"}} id=text-b704fe78e5 class=cmp-text>

The Biomedical Research Informatics Center (BRIC) is a vital resource supporting innovative research at 91´óÉñ Children’s. We provide specialized expertise, computational tools, and a robust data infrastructure that helps researchers unlock new insights and accelerate groundbreaking discoveries. Ìý

Our team collaborates with basic scientists, clinicians, and data experts across 91´óÉñ and national research networks like PEDSnet. We leverage advanced analytics, bioinformatics, biostatistics, and machine learning to uncover meaningful, actionable information from large datasets like electronic health records (EHR), genomic sequencing, and clinical observations.Ìý

BRIC plays an important role in 91´óÉñ precision medicine initiatives. Our work helps to develop disease biomarkers and identify promising treatments. We also fuel multisite clinical trials and studies aimed at improving care and health outcomes for kids.Ìý

With a world-class computational infrastructure, cutting-edge software, and specialized training, our team empowers researchers to solve complex pediatric health challenges.Ìý

Our research leverages advanced informatics and data science to tackle complex pediatric health challenges. We transform vast amounts of clinical and research data into meaningful insights. Through our focus areas, collaborative studies, and funded initiatives, we drive discoveries that improve children's health care outcomes.</p>\r\n<h2>Focus&nbsp;Areas&nbsp;</h2>\r\n<p>Our center focuses on key areas, such as:</p>\r\n<ul>\r\n<li><b>Biomedical data science:</b> Developing data integration platforms and applying machine learning to analyze pediatric health data from EHRs and multiple sources.</li>\r\n<li><b>Statistical innovation: </b>Creating novel approaches for modeling health trajectories and discovering patterns in longitudinal pediatric data.</li>\r\n<li><b>Precision medicine: </b>Integrating genomics, bioinformatics, and pharmacogenomics for individualized diagnostics and treatments.</li>\r\n<li><b>Research informatics infrastructure:</b> Maintaining high-performance computing resources and developing specialized applications for collaborative research.</li>\r\n<li><b>Geospatial analysis:</b> Combining geographic information with clinical data to understand environmental exposures and disease patterns.</li>\r\n<li><b>Natural language processing:</b> Extracting meaningful data from clinical notes and patient records for comprehensive research.</li>\r\n<li><b>Health trajectory modeling: </b>Tracking and predicting changes in health measures over time for individual patients and communities.</li>\r\n</ul>\r\n"}} id=text-b9ebaf1db7 class=cmp-text>

Our research leverages advanced informatics and data science to tackle complex pediatric health challenges. We transform vast amounts of clinical and research data into meaningful insights. Through our focus areas, collaborative studies, and funded initiatives, we drive discoveries that improve children's health care outcomes.

FocusÌýAreasÌý

Our center focuses on key areas, such as:

• Biomedical data science: Developing data integration platforms and applying machine learning to analyze pediatric health data from EHRs and multiple sources.
• Statistical innovation: Creating novel approaches for modeling health trajectories and discovering patterns in longitudinal pediatric data.
• Precision medicine: Integrating genomics, bioinformatics, and pharmacogenomics for individualized diagnostics and treatments.
• Research informatics infrastructure: Maintaining high-performance computing resources and developing specialized applications for collaborative research.
• Geospatial analysis: Combining geographic information with clinical data to understand environmental exposures and disease patterns.
• Natural language processing: Extracting meaningful data from clinical notes and patient records for comprehensive research.
• Health trajectory modeling: Tracking and predicting changes in health measures over time for individual patients and communities.

We accelerate translational research through multi-institutional collaborations across cardiology, pulmonology, endocrinology, oncology, hematology, perinatal health, and more. By integrating advanced analytics with clinical expertise, we empower health care providers with tools and insights that improve diagnosis, treatment, and prevention for a wide range of pediatric conditions.</p>\r\n<p><b>As a center, our overarching goals are to:</b></p>\r\n<ul>\r\n<li>Accelerate translational research through advanced informatics.</li>\r\n<li>Enable precision medicine for pediatric patients.</li>\r\n<li>Foster collaborative pediatric research networks.</li>\r\n<li>Provide cutting-edge computational resources and expertise.</li>\r\n<li>Integrate genomics and electronic health data for pediatric research.</li>\r\n<li>Support data-driven clinical trials and observational studies.</li>\r\n<li>Empower researchers with informatics tools and training.</li>\r\n</ul>\r\n"}} id=text-eb5465c4ba class=cmp-text>

We accelerate translational research through multi-institutional collaborations across cardiology, pulmonology, endocrinology, oncology, hematology, perinatal health, and more. By integrating advanced analytics with clinical expertise, we empower health care providers with tools and insights that improve diagnosis, treatment, and prevention for a wide range of pediatric conditions.

As a center, our overarching goals are to:

• Accelerate translational research through advanced informatics.
• Enable precision medicine for pediatric patients.
• Foster collaborative pediatric research networks.
• Provide cutting-edge computational resources and expertise.
• Integrate genomics and electronic health data for pediatric research.
• Support data-driven clinical trials and observational studies.
• Empower researchers with informatics tools and training.

We enable research through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. We engage with many notable grants, including:&nbsp;</p>\r\n<h3><b>PEDSnet:</b> A Pediatric Learning Health System</h3>\r\n<h3>&nbsp;</h3>\r\n<h3>National Institutes of Health (NIH)</h3>\r\n<p><b>IDeA Networks of Biomedical Research Excellence (INBRE) for Clinical and Translational Research (CTR)</b></p>\r\n<p><b>Centers of Biomedical Research Excellence (COBRE): Sickle Cell</b></p>\r\n"}} id=text-ed408fd0d7 class=cmp-text>

We enable research through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. We engage with many notable grants, including:Ìý

PEDSnet: A Pediatric Learning Health System

Ìý

National Institutes of Health (NIH)

IDeA Networks of Biomedical Research Excellence (INBRE) for Clinical and Translational Research (CTR)

Centers of Biomedical Research Excellence (COBRE): Sickle Cell

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.</p>\r\n"}} id=text-d3c760b9e1 class=cmp-text>

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices, and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.

BRIC supports 91´óÉñ Children's researchers across the Delaware Valley, North Florida, and Central Florida regions. Through four specialized cores, we provide essential services in clinical research data analytics, research data management, biostatistics, and bioinformatics.</p>\r\n<p>We offer end-to-end data management and analytical support throughout the research lifecycle, from study design to publication. Our expertise in advanced methodologies, data science approaches, and analytical software empowers researchers to achieve their objectives and drive advancements in pediatric medicine.</p>\r\n"}} id=text-c5822521ea class=cmp-text>

BRIC supports 91´óÉñ Children's researchers across the Delaware Valley, North Florida, and Central Florida regions. Through four specialized cores, we provide essential services in clinical research data analytics, research data management, biostatistics, and bioinformatics.

We offer end-to-end data management and analytical support throughout the research lifecycle, from study design to publication. Our expertise in advanced methodologies, data science approaches, and analytical software empowers researchers to achieve their objectives and drive advancements in pediatric medicine.

Our comprehensive services enable cutting-edge biomedical research by ensuring robust data handling, sophisticated analytical techniques, and seamless interdisciplinary collaboration. Our core services include:</p>\r\n<h3>Clinical Research Data Analytics Core</h3>\r\n<ul>\r\n<li>Data retrieval and management of electronic health records and national data registries</li>\r\n<li>Advanced analytics including natural language processing and geospatial analyses</li>\r\n<li>Data visualization through interactive dashboards and maps</li>\r\n</ul>\r\n<h3>Research Infrastructure &amp; Data Management Core</h3>\r\n<ul>\r\n<li>REDCap survey and database support</li>\r\n<li>Management and exchange of multimodal datasets</li>\r\n</ul>\r\n<h3>Biostatistics Core<br>\r\n</h3>\r\n<ul>\r\n<li>Study design and conduct</li>\r\n<li>Data processing and analysis</li>\r\n<li>Research dissemination support</li>\r\n<li>Training and instruction in statistical design and software (SAS, R, Python, SPSS, STATA, M-Plus, and Excel)</li>\r\n<li>Advanced statistical methodologies (linear/non-linear modeling, machine learning, Bayesian methods, survival analysis, and stochastic processes)</li>\r\n</ul>\r\n<h3>Bioinformatics Core</h3>\r\n<ul>\r\n<li>Biological data analysis</li>\r\n<li>Pipeline development</li>\r\n<li>Custom software development</li>\r\n</ul>\r\n"}} id=text-1ea6f8d97e class=cmp-text>

Our comprehensive services enable cutting-edge biomedical research by ensuring robust data handling, sophisticated analytical techniques, and seamless interdisciplinary collaboration. Our core services include:

Clinical Research Data Analytics Core

• Data retrieval and management of electronic health records and national data registries
• Advanced analytics including natural language processing and geospatial analyses
• Data visualization through interactive dashboards and maps

Research Infrastructure & Data Management Core

• REDCap survey and database support
• Management and exchange of multimodal datasets

Biostatistics Core

• Study design and conduct
• Data processing and analysis
• Research dissemination support
• Training and instruction in statistical design and software (SAS, R, Python, SPSS, STATA, M-Plus, and Excel)
• Advanced statistical methodologies (linear/non-linear modeling, machine learning, Bayesian methods, survival analysis, and stochastic processes)

Bioinformatics Core

• Biological data analysis
• Pipeline development
• Custom software development

Core labs and services at 91´óÉñ provide essential capabilities that advance pediatric research. Explore additional resources available to investigators across the system.</p>\r\n"}} id=text-8c9a7dc5cf class=cmp-text>

Core labs and services at 91´óÉñ provide essential capabilities that advance pediatric research. Explore additional resources available to investigators across the system.

The strength of our research lies in our connections and capabilities. Through strategic partnerships with clinical departments, academic institutions, and research networks, we amplify our impact on pediatric health. These collaborations are powered by robust computational infrastructure and specialized research tools that enable innovative, data-driven research at scale.</p>\r\n"}} id=text-9c7fb28434 class=cmp-text>

The strength of our research lies in our connections and capabilities. Through strategic partnerships with clinical departments, academic institutions, and research networks, we amplify our impact on pediatric health. These collaborations are powered by robust computational infrastructure and specialized research tools that enable innovative, data-driven research at scale.

We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study.&nbsp;</p>\r\n<h3>Internal Partners</h3>\r\n<p>Internally, we partner closely with 91´óÉñ clinicians and researchers:</p>\r\n<ul>\r\n<li><b>Cardiology: </b><a href=\"/content/nemours/us/en/find-a-researcher/researcher-profile.27180.html\" target=\"_self\" rel=\"noopener noreferrer\">Carissa M. Baker-Smith</a>,&nbsp;MD, MPH</li>\r\n<li><b>General Surgery:</b>&nbsp;<a href=\"/content/nemours/us/en/find-a-researcher/researcher-profile.41269.html\">Lori Gurien</a>, MD<a href=\"/content/nemours/us/en/find-a-researcher/researcher-profile.41269.html\" target=\"_self\" rel=\"noopener noreferrer\"></a></li>\r\n<li><b>Hematology/Oncology: </b><a href=\"/content/nemours/us/en/find-a-researcher/researcher-profile.54061.html\">David Brousseau</a>, MD</li>\r\n<li><b>Otolaryngology:</b> <a href=\"/content/nemours/us/en/find-a-researcher/researcher-profile.46982.html\" target=\"_self\" rel=\"noopener noreferrer\">Evie Landry</a>, MD</li>\r\n</ul>\r\n<h3>External Collaborations</h3>\r\n<p>Moving beyond our walls, we collaborate with recognized academic institutions and national institutes. This expands our reach and advances innovation for the collective good of children everywhere. We currently work with:</p>\r\n<ul>\r\n<li><a href=\"https://christianacare.org/us/en\" target=\"_blank\" rel=\"noopener noreferrer\">ChristianaCare</a>, Wilmington, Delaware&nbsp;</li>\r\n<li><a href=\"https://covid.cd2h.org\" target=\"_blank\" rel=\"noopener noreferrer\">National COVID Cohort Collaborative (N3C)</a></li>\r\n<li><a href=\"https://www.desu.edu/academics/academic-affairs/research\" target=\"_blank\" rel=\"noopener noreferrer\">Delaware State University</a>, Dover, Delaware&nbsp;</li>\r\n<li><a href=\"https://research.jefferson.edu/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Thomas Jefferson University</a>, Philadelphia, Pennsylvania</li>\r\n<li><a href=\"https://www.pcori.org\" target=\"_blank\" rel=\"noopener noreferrer\">Patient-Centered Outcomes Research Institute</a> (PCORI)</li>\r\n<li><a href=\"https://pedsnet.org\" target=\"_blank\" rel=\"noopener noreferrer\">PEDSnet: A Pediatric Learning Health System</a>&nbsp;</li>\r\n<li><a href=\"https://www.ucf.edu/research/\" target=\"_blank\" rel=\"noopener noreferrer\">University of Central Florida</a>, Orlando</li>\r\n<li><a href=\"https://www.udel.edu/research-innovation/\" target=\"_blank\" rel=\"noopener noreferrer\">University of Delaware</a>, Newark, Delaware</li>\r\n<li><a href=\"https://research.ufl.edu\" target=\"_blank\" rel=\"noopener noreferrer\">University of Florida,</a> Gainesville, Florida</li>\r\n</ul>\r\n"}} id=text-5845e4e294 class=cmp-text>

We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study.Ìý

Internal Partners

Internally, we partner closely with 91´óÉñ clinicians and researchers:

• Cardiology: Carissa M. Baker-Smith,ÌýMD, MPH
• General Surgery:ÌýLori Gurien, MD
• Hematology/Oncology: David Brousseau, MD
• Otolaryngology: Evie Landry, MD

External Collaborations

Moving beyond our walls, we collaborate with recognized academic institutions and national institutes. This expands our reach and advances innovation for the collective good of children everywhere. We currently work with:

• , Wilmington, DelawareÌý
• , Dover, DelawareÌý
• , Philadelphia, Pennsylvania
• (PCORI)
• Ìý
• , Orlando
• , Newark, Delaware
• Gainesville, Florida

Our center maintains state-of-the-art computational infrastructure and specialized research tools to support complex pediatric research. From high-performance computing to advanced analytics software, we provide the technical foundation that enables innovative data science, bioinformatics, and clinical research.</p>\r\n<h3>Computational Infrastructure&nbsp;</h3>\r\n<p>We have significant computational power and data storage capacity to support demanding pediatric research projects, including:</p>\r\n<ul>\r\n<li>High-performance computing cluster with significant GPU capacity for genomic analyses, predictive modeling, speech processing, and deep learning.</li>\r\n<li>Dedicated web/computing and database servers with substantial processing power and storage.</li>\r\n</ul>\r\n<h3>Research Tools &amp; Technologies</h3>\r\n<p>Our center leverages a wide range of specialized software, programming languages, and database platforms to advanced data management, integration, and analysis, including:</p>\r\n<ul>\r\n<li>Statistical/analytics software: SPSS, SAS, R, Bioconductor</li>\r\n<li>Programming languages: Python, R, C/C++, Java, etc.</li>\r\n<li>Database technologies: MySQL, PostgreSQL, REDCap</li>\r\n</ul>\r\n"}} id=text-4de4ad1c32 class=cmp-text>

Our center maintains state-of-the-art computational infrastructure and specialized research tools to support complex pediatric research. From high-performance computing to advanced analytics software, we provide the technical foundation that enables innovative data science, bioinformatics, and clinical research.

Computational InfrastructureÌý

We have significant computational power and data storage capacity to support demanding pediatric research projects, including:

• High-performance computing cluster with significant GPU capacity for genomic analyses, predictive modeling, speech processing, and deep learning.
• Dedicated web/computing and database servers with substantial processing power and storage.

Research Tools & Technologies

Our center leverages a wide range of specialized software, programming languages, and database platforms to advanced data management, integration, and analysis, including:

• Statistical/analytics software: SPSS, SAS, R, Bioconductor
• Programming languages: Python, R, C/C++, Java, etc.
• Database technologies: MySQL, PostgreSQL, REDCap