91´óÉñ

The Center for Pediatric Lung Research at 91´óÉñ Children’s is transforming how we understand and treat children’s breathing problems. Our work bridges the gap between laboratory discovery and bedside care. We bring innovative solutions directly to babies, children and teens with complex respiratory conditions.&nbsp;</p>\r\n<p>Partnering with specialists across 91´óÉñ and leading institutions like Thomas Jefferson University and the University of Delaware, our diverse team of scientists and doctors work together to approach the most challenging pediatric lung conditions. We combine leading-edge laboratory research with real-world clinical studies, using everything from advanced cell models to child-sized animal studies to find new treatments.&nbsp;</p>\r\n<p>We make a real difference in children's care. For example, we developed a quick, gentle breathing monitoring technology that takes just 5-10 minutes and requires no difficult tests. When used with premature infants on oxygen therapy, 62% showed improved breathing patterns, allowing doctors to adjust oxygen support in real time for better outcomes.</p>\r\n<p>Our team is dedicated to solving today’s challenges in children’s breathing care, while also conducting forward-looking research to unlock future discoveries. Whether we’re developing new imaging methods, helping doctors adjust oxygen therapy for premature babies, or studying new treatments for rare lung diseases, we’re helping kids breathe easier and live healthier lives.</p>\r\n"}} id=text-4e4016d905 class=cmp-text>

The Center for Pediatric Lung Research at 91´óÉñ Children’s is transforming how we understand and treat children’s breathing problems. Our work bridges the gap between laboratory discovery and bedside care. We bring innovative solutions directly to babies, children and teens with complex respiratory conditions.Ìý

Partnering with specialists across 91´óÉñ and leading institutions like Thomas Jefferson University and the University of Delaware, our diverse team of scientists and doctors work together to approach the most challenging pediatric lung conditions. We combine leading-edge laboratory research with real-world clinical studies, using everything from advanced cell models to child-sized animal studies to find new treatments.Ìý

We make a real difference in children's care. For example, we developed a quick, gentle breathing monitoring technology that takes just 5-10 minutes and requires no difficult tests. When used with premature infants on oxygen therapy, 62% showed improved breathing patterns, allowing doctors to adjust oxygen support in real time for better outcomes.

Our team is dedicated to solving today’s challenges in children’s breathing care, while also conducting forward-looking research to unlock future discoveries. Whether we’re developing new imaging methods, helping doctors adjust oxygen therapy for premature babies, or studying new treatments for rare lung diseases, we’re helping kids breathe easier and live healthier lives.

Our center combines clinical innovation, targeted investigations and laboratory breakthroughs to improve respiratory care for children. We translate scientific discovery into better treatments.</p>\r\n<h2>Focus Areas</h2>\r\n<p>Through advanced technology and specialized resources, our team pioneers new ways to assess and understand children's breathing challenges. Our focus areas include:</p>\r\n<ul>\r\n<li><b>Basic lung development:</b>&nbsp;Investigating cellular mechanisms and development processes to prevent respiratory disorders children, with emphasis on premature infant care.</li>\r\n<li><b>Treatment innovation:</b>&nbsp;Advancing respiratory support technologies and medications through integrated clinical research and real-time assessment methodologies.</li>\r\n<li><b>Special population care:&nbsp;</b>Developing targeted interventions for children with rare diseases, neuromuscular conditions, and complex respiratory needs.</li>\r\n<li><b>Assessment technology:&nbsp;</b>Creating and validating noninvasive monitoring tools and improving respiratory care delivery for kids of all ages.</li>\r\n</ul>\r\n"}} id=text-ac3b0a8c41 class=cmp-text>

Our center combines clinical innovation, targeted investigations and laboratory breakthroughs to improve respiratory care for children. We translate scientific discovery into better treatments.

Focus Areas

Through advanced technology and specialized resources, our team pioneers new ways to assess and understand children's breathing challenges. Our focus areas include:

• Basic lung development:ÌýInvestigating cellular mechanisms and development processes to prevent respiratory disorders children, with emphasis on premature infant care.
• Treatment innovation:ÌýAdvancing respiratory support technologies and medications through integrated clinical research and real-time assessment methodologies.
• Special population care:ÌýDeveloping targeted interventions for children with rare diseases, neuromuscular conditions, and complex respiratory needs.
• Assessment technology:ÌýCreating and validating noninvasive monitoring tools and improving respiratory care delivery for kids of all ages.

Our research priorities target two critical areas: understanding pediatric respiratory system development and creating more effective treatments. We operate generally under these research themes:</p>\r\n<ul>\r\n<li><b>Bench to bedside translation:</b> Accelerating laboratory discoveries into patient care through integrated clinical and research programs.</li>\r\n<li><a href=\"/content/nemours/us/en/pediatric-research/research-labs/noninvasive-pulmonary-evaluation.html\"><b>Noninvasive innovation</b></a><b>:</b> Creating gentle, effective methods to monitor and treat breathing problems in children.</li>\r\n<li><b>Interdisciplinary collaboration:</b> Combining expertise across medical specialties and research institutions to solve complex respiratory challenges.</li>\r\n<li><b>Real-time assessment:</b> Developing new technologies that allow for immediate evaluation and adjustment for better care.</li>\r\n</ul>\r\n"}} id=text-f27f79e714 class=cmp-text>

Our research priorities target two critical areas: understanding pediatric respiratory system development and creating more effective treatments. We operate generally under these research themes:

• Bench to bedside translation: Accelerating laboratory discoveries into patient care through integrated clinical and research programs.
• Noninvasive innovation: Creating gentle, effective methods to monitor and treat breathing problems in children.
• Interdisciplinary collaboration: Combining expertise across medical specialties and research institutions to solve complex respiratory challenges.
• Real-time assessment: Developing new technologies that allow for immediate evaluation and adjustment for better care.

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.</p>\r\n"}} id=text-f3d64b6b27 class=cmp-text>

Pediatric clinical trials and research studies are important for advancing medical knowledge and improving care for kids around the world. Our researchers lead clinical research to study new drugs, treatments, devices and techniques. We also contribute to national registries and collaboratives to further research in this area. Find a clinical trial or study now.

We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study.</p>\r\n<h3><b>Internal&nbsp;Partners</b></h3>\r\n<p>Within the 91´óÉñ system we’ve established robust cross-disciplinary research partnerships with specialists in:</p>\r\n<ul>\r\n<li><b>Anesthesiology:&nbsp;</b><a href=\"/content/nemours/us/en/find-a-doctor/provider-profile.2376.html\" rel=\"noopener noreferrer\">Mary Theroux, MD</a></li>\r\n<li><b>Neonatology</b></li>\r\n<li><b>Pediatric Critical Care</b></li>\r\n<li><b>Pulmonary Medicine</b></li>\r\n<li><b>Orthopedics</b></li>\r\n<li><b>Emergency Medicine</b></li>\r\n<li><b>Rare Diseases</b></li>\r\n</ul>\r\n<h3><b>External Partners</b></h3>\r\n<p>Moving beyond our walls, we collaborate with scientific leaders from other institutions. This expands our reach and advances innovation for the collective good of children everywhere. We currently work with:</p>\r\n<ul>\r\n<li><a href=\"https://research.jefferson.edu/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Thomas Jefferson University</a>, Philadelphia, Pennsylvania.</li>\r\n<li><a href=\"https://www.udel.edu/research-innovation/\" target=\"_blank\" rel=\"noopener noreferrer\">The University of Delaware</a>, Newark, Delaware</li>\r\n<li><a href=\"https://christianacare.org/us/en\" target=\"_blank\" rel=\"noopener noreferrer\">ChristianaCare</a>, Wilmington, Delaware</li>\r\n<li><a href=\"https://research.temple.edu/\" target=\"_blank\" rel=\"noopener noreferrer\">Temple University</a>, Philadelphia, Pennsylvania</li>\r\n<li><a href=\"https://www.nigms.nih.gov/Research/DRCB/IDeA/pages/INBRE.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">NIH Institutional Award Development (IDeA) program</a>, Bethesda, Maryland.</li>\r\n</ul>\r\n"}} id=text-e79c01c930 class=cmp-text>

We expand our knowledge and leverage diverse perspectives with partnerships and collaborations within and outside our field of study.

InternalÌýPartners

Within the 91´óÉñ system we’ve established robust cross-disciplinary research partnerships with specialists in:

• Anesthesiology:ÌýMary Theroux, MD
• Neonatology
• Pediatric Critical Care
• Pulmonary Medicine
• Orthopedics
• Emergency Medicine
• Rare Diseases

External Partners

Moving beyond our walls, we collaborate with scientific leaders from other institutions. This expands our reach and advances innovation for the collective good of children everywhere. We currently work with:

• , Philadelphia, Pennsylvania.
• , Newark, Delaware
• , Wilmington, Delaware
• , Philadelphia, Pennsylvania
• , Bethesda, Maryland.

Centers at 91´óÉñ often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.</p>\r\n"}} id=text-7336328195 class=cmp-text>

Centers at 91´óÉñ often align with research areas, affiliated labs, and clinical programs to support discovery and care systemwide.

Through robust research projects, patented technologies and clinical innovations, our center drives pediatric respiratory medicine forward. Our impact spans diagnostic tools to novel therapeutic approaches, with several patents granted and numerous federally funded studies.&nbsp;</p>\r\n<p>We actively share our knowledge through international presentations and publications, which translate scientific discoveries into improved care for children with respiratory conditions. Some of our more notable impacts include:</p>\r\n<ul>\r\n<li>Pioneered novel PET imaging techniques for neurofibromatosis type 1, improving diagnostic accuracy.</li>\r\n<li>Developed new methods to assess respiratory function in children with cerebral palsy.</li>\r\n<li>Created breakthrough approach for visualizing SARS-CoV-2 receptor distribution via PET imaging.</li>\r\n<li>Established optimized protocols for high-flow nasal cannula therapy in clinical settings.</li>\r\n<li>Advanced respiratory support technologies for premature infants through innovative device development.</li>\r\n<li>Designed and patented novel treatments for respiratory depression.</li>\r\n<li>Developed real-time respiratory monitoring system that improved breathing outcomes in 62% of premature infants receiving oxygen therapy.</li>\r\n<li>Developed extrathoracic augmentation techniques for respiratory support.</li>\r\n<li>Created non-invasive cerebral cooling methods for therapeutic applications.</li>\r\n<li>Established biofeedback protocols for youth with chronic respiratory conditions.</li>\r\n<li>Advanced understanding of pulmonary dysfunction in Morquio A syndrome.</li>\r\n<li>Pioneered new approaches to alveolar epithelial cell research.</li>\r\n</ul>\r\n"}} id=text-6450dc5e60 class=cmp-text>

Through robust research projects, patented technologies and clinical innovations, our center drives pediatric respiratory medicine forward. Our impact spans diagnostic tools to novel therapeutic approaches, with several patents granted and numerous federally funded studies.Ìý

We actively share our knowledge through international presentations and publications, which translate scientific discoveries into improved care for children with respiratory conditions. Some of our more notable impacts include:

• Pioneered novel PET imaging techniques for neurofibromatosis type 1, improving diagnostic accuracy.
• Developed new methods to assess respiratory function in children with cerebral palsy.
• Created breakthrough approach for visualizing SARS-CoV-2 receptor distribution via PET imaging.
• Established optimized protocols for high-flow nasal cannula therapy in clinical settings.
• Advanced respiratory support technologies for premature infants through innovative device development.
• Designed and patented novel treatments for respiratory depression.
• Developed real-time respiratory monitoring system that improved breathing outcomes in 62% of premature infants receiving oxygen therapy.
• Developed extrathoracic augmentation techniques for respiratory support.
• Created non-invasive cerebral cooling methods for therapeutic applications.
• Established biofeedback protocols for youth with chronic respiratory conditions.
• Advanced understanding of pulmonary dysfunction in Morquio A syndrome.
• Pioneered new approaches to alveolar epithelial cell research.

Our research is recognized and validated through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has recently been awarded:&nbsp;</p>\r\n<h3>National Heart, Lung, and Blood Institute (NHLBI)</h3>\r\n<p><b>KO8 Award |&nbsp;</b>Role of alveolar epithelial cell-derived CCN2 in lung development (2020-2025) | Alapati, D. (PI)</p>\r\n<h3>National Institute of Child Health and Human Development (NICHD)&nbsp;</h3>\r\n<p><b>R21 Grant |&nbsp;</b>Non-Invasive Pulmonary Assessment in Cerebral Palsy (2023-2025) | Rahman, T. (PI)&nbsp;</p>\r\n<p><b>R01 Grant |&nbsp;</b>Functional Assessment of Morquio A Syndrome (2021-2026) | Tomatsu, S. (PI)&nbsp;</p>\r\n<h3>National Institute of Biomedical Imaging and Bioengineering (NIBIB)&nbsp;</h3>\r\n<p><b>R21 Grant |&nbsp;</b>PET Imaging of COVID-19 Entry Receptors (2021-2025) | Yue, X. (PI)</p>\r\n<h3>National Institute of General Medical Sciences (NIGMS)&nbsp;</h3>\r\n<p><b>P20 Grant |&nbsp;</b>PET Imaging Probes for Lymphatic System (2024-2025) | Duncan, M. (PI)</p>\r\n<h3>Industry Sponsored Research&nbsp;</h3>\r\n<p><b>Vapotherm, Inc.<br>\r\n </b>High-Flow Nasal Cannula Impact on Cardiac Output (2023-2025) | Levenbrown, Y. (PI)&nbsp;</p>\r\n<p><b>Enalare Therapeutics, Inc<br>\r\n </b>ENA-001 Safety Margins in Respiratory Depression (2023-2024) | Shaffer, T. (PI)&nbsp;</p>\r\n"}} id=text-affa0afe5d class=cmp-text>

Our research is recognized and validated through generous grants. This support moves us forward and allows us to meaningfully contribute to scientific discovery. Our team has recently been awarded:Ìý

National Heart, Lung, and Blood Institute (NHLBI)

KO8 Award |ÌýRole of alveolar epithelial cell-derived CCN2 in lung development (2020-2025) | Alapati, D. (PI)

National Institute of Child Health and Human Development (NICHD)Ìý

R21 Grant |ÌýNon-Invasive Pulmonary Assessment in Cerebral Palsy (2023-2025) | Rahman, T. (PI)Ìý

R01 Grant |ÌýFunctional Assessment of Morquio A Syndrome (2021-2026) | Tomatsu, S. (PI)Ìý

National Institute of Biomedical Imaging and Bioengineering (NIBIB)Ìý

R21 Grant |ÌýPET Imaging of COVID-19 Entry Receptors (2021-2025) | Yue, X. (PI)

National Institute of General Medical Sciences (NIGMS)Ìý

P20 Grant |ÌýPET Imaging Probes for Lymphatic System (2024-2025) | Duncan, M. (PI)

Industry Sponsored ResearchÌý

Vapotherm, Inc.
High-Flow Nasal Cannula Impact on Cardiac Output (2023-2025) | Levenbrown, Y. (PI)Ìý

Enalare Therapeutics, Inc
ENA-001 Safety Margins in Respiratory Depression (2023-2024) | Shaffer, T. (PI)Ìý