91大神

Anilkumar Gopalakrishnapillai

Research Scientist

91大神 Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Dr. Gopalakrishnapillai is currently serving as head of Cancer Stem Cell Laboratory at 91大神 Children's Hospital. He completed his Ph.D at Indian Institute of Science, Bangalore, India, postdoctoral research at University of California, Los Angeles and served as Associate Professor leading a lab in India, before joining 91大神 in 2012. His Current research is centered around developing novel targeted therapies for Down syndrome Myeloid Leukemia (DS-ML). He uses several strategies for developing disease models for DS-ML to understand disease biogenesis. Also actively engaged in characterizing the DS-ML stem cell population with a goal of specifically eradicating this population as a strategy to control disease relapse.

Medical/Dental School

  • Ph.D - Indian Institute of Science
  • Post Graduate Researcher - University of California

  • Leukemia, Hematological Malignancies Preclinical Model, Ipsc Disease Models, Cr

  • Down syndrome and leukemia: An insight into the disease biology and current treatment options.; Blood reviews; (2023).

  • Tetraspanins set the stage for bone marrow microenvironment-induced chemoprotection in hematologic malignancies.; Blood advances; (2023).

  • Bone Marrow Microenvironment-Induced Chemoprotection in <i>KMT2A</i> Rearranged Pediatric AML Is Overcome by Azacitidine鈥揚anobinostat Combination; Cancers; (2023).

  • Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts; Journal of Clinical Medicine; (2022).

  • Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of <i>GATA1</i> and <i>STAG2</i> Mutations in Induced Pluripotent Stem Cells with Trisomy 21; Cells; (2022).

  • Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia; Journal of Clinical Medicine; (2022).

  • Mesothelin: An Immunotherapeutic Target beyond Solid Tumors; Cancers; (2022).

  • Mesothelin is a novel cell surface disease marker and potential therapeutic target in Acute Myellid Leukemia; Blood advances; (2021).

  • Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies; Cancers; (2021).

  • Harnessing the Power of Induced Pluripotent Stem Cells and Gene Editing Technology: Therapeutic Implications in Hematological Malignancies; Cells; (2021).

  • The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML; Blood; (2021).

  • A 3-D hydrogel based system for hematopoietic differentiation and its use in modeling down syndrome associated transient myeloproliferative disorder; Biomaterials Science; (2021).

  • Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring.; BMC medical genomics; (2020).

  • CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia.; Blood advances; (2020).

  • Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology.; Molecular therapy. Methods & clinical development; (2020).

  • Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer.; Frontiers in oncology; (2020).

  • Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples.; Genomics & informatics; (2020).

  • The extracellular matrix: A key player in the pathogenesis of hematologic malignancies.; Blood reviews; (2020).

  • Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia.; Leukemia research; (2017).

  • Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia.; Leukemia research; (2017).

  • CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome.; Molecular therapy. Nucleic acids; (2017).

  • Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.; Seminars in oncology; (2017).

  • Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells.; The Journal of biological chemistry; (2017).

  • Generation of Pediatric Leukemia Xenograft Models in NSG-B2m Mice: Comparison with NOD/SCID Mice.; Frontiers in oncology; (2016).

  • Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.; PloS one; (2015).

  • Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.; The Journal of biological chemistry; (2015).

  • Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration.; American journal of physiology. Cell physiology; (2015).

  • Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity.; Cancer & metabolism; (2014).

  • Ellagic acid stimulates glucose transport in adipocytes and muscles through AMPK mediated pathway; Journal of diabetes and metabolism; (2012).

  • A Comprehensive Curated Reaction Map of Leptin Signaling Pathway; Jornal of Proteomics and bioinformatics; (2011).

  • Elucidation of the glucose transport pathway in glucose transporter 4 via steered molecular dynamics simulations.; PloS one; (2011).

  • Association analysis of common variants in FOXO3 with type 2 diabetes in a South Indian Dravidian population.; Gene; (2011).

  • Vanillin induces adipocyte differentiation in 3T3-L1 cells by activating extracellular signal regulated kinase 42/44.; Life sciences; (2011).

  • Molecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibition.; PloS one; (2010).

  • A case-control analysis of common variants in GIP with type 2 diabetes and related biochemical parameters in a South Indian population.; BMC medical genetics; (2010).

  • Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population.; PloS one; (2010).

  • Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes.; Biochemical and biophysical research communications; (2009).

  • Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors.; Journal of biomolecular structure & dynamics; (2009).

  • Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells.; FEBS letters; (2009).

  • Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix.; International journal of oncology; (2007).

  • Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis.; FEMS microbiology letters; (2006).

  • Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature.; Microvascular research; (2006).

  • Is prostate-specific membrane antigen a multifunctional protein?; American journal of physiology. Cell physiology; (2005).

  • N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy.; Molecular cancer therapeutics; (2005).

  • Genomic organization and in vivo characterization of proteolytic activity of FtsH of Mycobacterium smegmatis SN2.; Microbiology (Reading, England); (2004).

  • Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.; Molecular biology of the cell; (2004).

  • A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.; Molecular biology of the cell; (2003).

  • Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity.; Cancer research; (2003).

  • Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH.; Microbiology (Reading, England); (2001).

  • Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv.; Gene; (1998).

  • Newly synthesised mRNA as a probe for identification of wound responsive genes from potatoes.; Indian journal of biochemistry & biophysics; (1995).